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It is used for treating impaired function of muscles of the small antibiotic vancomycin sphincter.

Tablets and syrup should be stored between 15-30 C (59-86
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F). The safety of metoclopramide in pregnancy has not been established. Metoclopramide is used on a short term basis (4 to 12 weeks) for treating patients with heartburn and esophagitis due to GERD and for treating
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patients who have
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gastroparesis. Dopamine receptors on nerves in the brain are important beta lactamase antibiotics in producing nausea. For example, the effects of alcohol, diazepam (Valium) and cyclosporine can be accelerated when used together with metoclopramide.
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The lower esophageal sphincter, located between the esophagus and the stomach, normally prevents reflux of acid and other contents in the stomach from backing up into the esophagus. The FDA approved metoclopramide in Nancee 1985. Metoclopramide should not be used in patients taking MAO inhibitors
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for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), because of the risk of serious adverse effects due to excess release of neurotransmitters. Metoclopramide also is used in the treatment of nausea due to surgery or cancer chemotherapy. Metoclopramide is generally
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well-tolerated when used in low doses for brief periods. Since metoclopramide accelerates emptying of the stomach, it can increase
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or decrease absorption and effects of other drugs that are absorbed in the small intestine. In patients with gastroesophageal reflux disease (GERD), a weakened lower esophageal sphincter allows reflux of stomach acid into
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the esophagus, causing heartburn and damage to the esophagus
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(esophagitis). Conversely, metoclopramide may decrease the concentrations in blood of digoxin (Lanoxin) and cimetidine (Tagamet). Metoclopramide interacts with the dopamine receptors in the brain and can be effective in treating nausea. Metoclopramide is a "prokinetic" drug that stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine by interacting
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with receptors for acetylcholine and dopamine on gastrointestinal muscles and nerves. The most serious neurological side effects of metoclopramide are symptoms mimicking Parkinson's disease, involuntary muscle movements, facial grimacing, and dystonic reactions resembling tetanus. Concurrent administration of anticholinergic drugs can decrease the effectiveness of metoclopramide. Nursing mothers should avoid metoclopramide during pregnancy. Metoclopramide is used to promote
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emptying of the stomach prior to radiological examinations and to facilitate passage of tubes passed through the nose or mouth and into the small intestine. In some patients, particularly those with diabetes, damage to nerves in the stomach can interfere with function of the muscles and cause delayed emptying of the stomach, resulting in nausea, vomiting, a sense of abdominal fullness and distention, and heartburn (diabetic gastroparesis). Fortunately, these more serious side effects are infrequent and usually - though not always - disappear when metoclopramide is discontinued. The usual dose of metoclopramide
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for treating GERD is 10-15 mg four times daily, 30 minutes before each meal. Patients with Parkinson's disease can experience worsening of symptoms with metoclopramide. Metoclopramide may impair the mental and/or physical abilities to drive or operate machinery.. Metoclopramide can be effective in relieving the symptoms related to diabetic gastroparesis by stimulating more rapid emptying of the stomach as well as decreasing the reflux of stomach acid into the esophagus. Injectable metoclopramide should be stored at room temperature 20-25 C (68-77 F). Gastroparesis is treated with 10 mg administered orally four times daily, 30 minutes before each meal and at bedtime.

Metoclopramide also stimulates the muscles of the stomach and thereby hastens emptying of solid and liquid meals from the stomach and into the intestines.